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How many do we miss? - Evaluation of age at onset and family history as selection criteria for genetic testing in Parkinson‘s disease

GP2 ❤️ Open Science 😍

License: MIT DOI

Last Updated: November 2025

Summary

This repository contains the code used in the study: “How many do we miss? - Evaluation of age at onset and family history as selection criteria for genetic testing in Parkinson‘s disease”.

Data Statement

  • The data was obtained from the Global Parkinson’s Genetics Program (GP2) release 9 (GP2 release 9, DOI: 10.5281/zenodo.14510099) and access can be requested through the Accelerating Medicines Partnership in Parkinson’s Disease (AMP-PD) via the online application process (https://www.amp-pd.org/).

Citation

[DOI: pending publication]

Helpful Links

Repository Orientation

  • The main code includes the .Rmd script discussed in the manuscript.
  • Data extraction from the GP2 was performed using notebooks described previously in the code accompanying "Exploring the Global Landscape of Rare Causal and Common High-Risk Variants in Parkinson’s Disease" manuscript (https://github.com/GP2code/GP2-global-genetic-variant-landscape).
THIS REPO
├── GenTestGP2_clean.Rmd
├── LICENSE
└── README.md

Analyses

  • Languages: R
Notebook Description
00_GenTestGP2_clean.Rmd Data analysis and plotting

Software

Software Version(s) Resource URL RRID Notes
R Project for Statistical Computing v.4.2.2 http://www.r-project.org/ RRID:SCR_001905 pROC, readxl, knitr, gdata, DescTools, openxlsx ; Used for general data wrangling/plotting/analyses