diff --git a/contracts/chain-adapters/OP_Adapter.sol b/contracts/chain-adapters/OP_Adapter.sol
index 0fcf1a975..e2f5c8818 100644
--- a/contracts/chain-adapters/OP_Adapter.sol
+++ b/contracts/chain-adapters/OP_Adapter.sol
@@ -35,31 +35,43 @@ contract OP_Adapter is CrossDomainEnabled, AdapterInterface, CircleCCTPAdapter {
     IL1StandardBridge public immutable L1_STANDARD_BRIDGE;
     IOpUSDCBridgeAdapter public immutable L1_OP_USDC_BRIDGE;
 
+    error InvalidBridgeConfig();
+
     /**
      * @notice Constructs new Adapter.
      * @param _l1Weth WETH address on L1.
+     * @param _l1Usdc USDC address on L1.
      * @param _crossDomainMessenger XDomainMessenger Destination chain system contract.
      * @param _l1StandardBridge Standard bridge contract.
-     * @param _l1Usdc USDC address on L1.
+     * @param _l1USDCBridge OP USDC bridge contract.
+     * @param _cctpTokenMessenger CCTP token messenger contract.
+     * @param _recipientCircleDomainId Circle domain ID of the destination chain.
      */
     constructor(
         WETH9Interface _l1Weth,
         IERC20 _l1Usdc,
         address _crossDomainMessenger,
         IL1StandardBridge _l1StandardBridge,
-        IOpUSDCBridgeAdapter _l1USDCBridge
+        IOpUSDCBridgeAdapter _l1USDCBridge,
+        ITokenMessenger _cctpTokenMessenger,
+        uint32 _recipientCircleDomainId
     )
         CrossDomainEnabled(_crossDomainMessenger)
-        CircleCCTPAdapter(
-            _l1Usdc,
-            // Hardcode cctp messenger to 0x0 to disable CCTP bridging.
-            ITokenMessenger(address(0)),
-            CircleDomainIds.UNINITIALIZED
-        )
+        CircleCCTPAdapter(_l1Usdc, _cctpTokenMessenger, _recipientCircleDomainId)
     {
         L1_WETH = _l1Weth;
         L1_STANDARD_BRIDGE = _l1StandardBridge;
         L1_OP_USDC_BRIDGE = _l1USDCBridge;
+
+        address zero = address(0);
+        if (address(_l1Usdc) != zero) {
+            bool opUSDCBridgeDisabled = address(_l1USDCBridge) == zero;
+            bool cctpUSDCBridgeDisabled = address(_cctpTokenMessenger) == zero;
+            // Bridged and Native USDC are mutually exclusive.
+            if (opUSDCBridgeDisabled == cctpUSDCBridgeDisabled) {
+                revert InvalidBridgeConfig();
+            }
+        }
     }
 
     /**
diff --git a/test/evm/foundry/local/OP_Adapter.t.sol b/test/evm/foundry/local/OP_Adapter.t.sol
new file mode 100644
index 000000000..e9a5aa8fd
--- /dev/null
+++ b/test/evm/foundry/local/OP_Adapter.t.sol
@@ -0,0 +1,95 @@
+// SPDX-License-Identifier: BUSL-1.1
+pragma solidity ^0.8.0;
+
+import { Test } from "forge-std/Test.sol";
+
+import { ERC20, IERC20 } from "@openzeppelin/contracts-v4/token/ERC20/ERC20.sol";
+import { IL1StandardBridge } from "@eth-optimism/contracts/L1/messaging/IL1StandardBridge.sol";
+import { IOpUSDCBridgeAdapter } from "../../../../contracts/external/interfaces/IOpUSDCBridgeAdapter.sol";
+import { ITokenMessenger } from "../../../../contracts/external/interfaces/CCTPInterfaces.sol";
+
+import { OP_Adapter } from "../../../../contracts/chain-adapters/OP_Adapter.sol";
+import { WETH9Interface } from "../../../../contracts/external/interfaces/WETH9Interface.sol";
+import { WETH9 } from "../../../../contracts/external/WETH9.sol";
+
+contract OP_AdapterTest is Test {
+    ERC20 l1Usdc;
+    WETH9 l1Weth;
+
+    IL1StandardBridge standardBridge;
+    IOpUSDCBridgeAdapter opUSDCBridge;
+    ITokenMessenger cctpMessenger;
+
+    uint32 constant RECIPIENT_CIRCLE_DOMAIN_ID = 1;
+
+    function setUp() public {
+        l1Usdc = new ERC20("l1Usdc", "l1Usdc");
+        l1Weth = new WETH9();
+
+        standardBridge = IL1StandardBridge(makeAddr("standardBridge"));
+        opUSDCBridge = IOpUSDCBridgeAdapter(makeAddr("opUSDCBridge"));
+        cctpMessenger = ITokenMessenger(makeAddr("cctpMessenger"));
+    }
+
+    function testUSDCNotSet() public {
+        new OP_Adapter(
+            WETH9Interface(address(l1Weth)),
+            IERC20(address(0)),
+            address(0),
+            standardBridge,
+            IOpUSDCBridgeAdapter(address(0)),
+            ITokenMessenger(address(0)),
+            RECIPIENT_CIRCLE_DOMAIN_ID
+        );
+    }
+
+    function testL1UsdcBridgeSet() public {
+        new OP_Adapter(
+            WETH9Interface(address(l1Weth)),
+            IERC20(address(l1Usdc)),
+            address(0),
+            standardBridge,
+            opUSDCBridge,
+            ITokenMessenger(address(0)),
+            RECIPIENT_CIRCLE_DOMAIN_ID
+        );
+    }
+
+    function testCctpMessengerSet() public {
+        new OP_Adapter(
+            WETH9Interface(address(l1Weth)),
+            IERC20(address(0)),
+            address(0),
+            standardBridge,
+            IOpUSDCBridgeAdapter(address(0)),
+            cctpMessenger,
+            RECIPIENT_CIRCLE_DOMAIN_ID
+        );
+    }
+
+    function testNeitherSet() public {
+        vm.expectRevert(OP_Adapter.InvalidBridgeConfig.selector);
+        new OP_Adapter(
+            WETH9Interface(address(l1Weth)),
+            IERC20(address(l1Usdc)),
+            address(0),
+            standardBridge,
+            IOpUSDCBridgeAdapter(address(0)),
+            ITokenMessenger(address(0)),
+            RECIPIENT_CIRCLE_DOMAIN_ID
+        );
+    }
+
+    function testBothSet() public {
+        vm.expectRevert(OP_Adapter.InvalidBridgeConfig.selector);
+        new OP_Adapter(
+            WETH9Interface(address(l1Weth)),
+            IERC20(address(l1Usdc)),
+            address(0),
+            standardBridge,
+            opUSDCBridge,
+            cctpMessenger,
+            RECIPIENT_CIRCLE_DOMAIN_ID
+        );
+    }
+}
diff --git a/test/evm/hardhat/chain-adapters/OP_Adapter.ts b/test/evm/hardhat/chain-adapters/OP_Adapter.ts
index c5e2778bd..e3b612ed5 100644
--- a/test/evm/hardhat/chain-adapters/OP_Adapter.ts
+++ b/test/evm/hardhat/chain-adapters/OP_Adapter.ts
@@ -12,9 +12,11 @@ import {
   toWei,
   getContractFactory,
   seedWallet,
+  toBN,
 } from "../../../../utils/utils";
 import { hubPoolFixture, enableTokensForLP } from "../fixtures/HubPool.Fixture";
 import { constructSingleChainTree } from "../MerkleLib.utils";
+import { ZERO_ADDRESS } from "@uma/common";
 
 let hubPool: Contract, adapter: Contract, weth: Contract, usdc: Contract, mockSpoke: Contract, timer: Contract;
 let l2Weth: string, l2Usdc: string;
@@ -63,7 +65,9 @@ describe("OP Adapter", function () {
       usdc.address,
       l1CrossDomainMessenger.address,
       l1StandardBridge.address,
-      opUSDCBridge.address
+      opUSDCBridge.address,
+      ZERO_ADDRESS,
+      toBN("322")
     );
     // Seed the HubPool some funds so it can send L1->L2 messages.
     await hubPool.connect(liquidityProvider).loadEthForL2Calls({ value: toWei("1") });