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├── pycentiloid/
│ ├── __init__.py
│ ├── config.py # Global configuration
│ ├── core/ # Core functionality
│ │ ├── __init__.py
│ │ ├── tracer.py # Tracer definitions and parameters
│ │ └── template.py # Template management
│ ├── preprocessing/ # Image preprocessing
│ │ ├── __init__.py
│ │ ├── registration.py # Spatial normalization
│ │ ├── segmentation.py # Brain segmentation
│ │ └── harmonization.py # Image harmonization
│ ├── atlas/ # Atlas management
│ │ ├── __init__.py
│ │ ├── manager.py # Atlas I/O and API
│ │ └── visualization.py # Atlas visualization
│ ├── centiloid/ # Centiloid calculation
│ │ ├── __init__.py
│ │ ├── calculation.py # Centiloid score calculation
│ │ ├── calibration.py # Centiloid calibration
│ │ ├── reference.py # Reference regions
│ │ └── suvr.py # SUVr calculation
│ ├── reporting/ # Report generation
│ │ ├── __init__.py
│ │ ├── generator.py # Report generation
│ │ ├── templates/ # Report templates
│ │ └── dicom_sr.py # DICOM SR generation
│ ├── workflows/ # Integrated workflows
│ │ ├── __init__.py
│ │ ├── centiloid.py # Centiloid calculation workflow
│ │ ├── template.py # Template generation workflow
│ │ ├── calibration.py # Calibration workflow
│ │ └── report.py # Reporting workflow
│ └── utils/ # Utility functions
│ ├── __init__.py
│ ├── dicom.py # DICOM utilities
│ ├── nifti.py # NIFTI utilities
│ ├── conversion.py # NIFTI <> DICOM conversion
│ ├── resolution.py # Resolution handling
│ └── validation.py # Input validation
├── data/ # Data directory
│ ├── templates/ # Template images
│ ├── masks/ # Mask images
│ └── atlases/ # Atlas data
├── docs/ # Documentation
├── tests/ # Unit tests
└── examples/ # Example scripts