diff --git a/flytekit/utils/asyn.py b/flytekit/utils/asyn.py
index 0ae25e9bb7..167d62e3e0 100644
--- a/flytekit/utils/asyn.py
+++ b/flytekit/utils/asyn.py
@@ -11,6 +11,7 @@ async def async_add(a: int, b: int) -> int:
 
 import asyncio
 import atexit
+import contextvars
 import functools
 import os
 import threading
@@ -95,8 +96,40 @@ def run_sync(self, coro_func: Callable[..., Awaitable[T]], *args, **kwargs) -> T
         """
         This should be called from synchronous functions to run an async function.
         """
-        name = threading.current_thread().name + f"PID:{os.getpid()}"
         coro = coro_func(*args, **kwargs)
+
+        # Detect if we're inside a running event loop (e.g., async web framework).
+        # In that case, the _TaskRunner approach can fail with
+        # "Cannot run the event loop while another loop is running",
+        # so we run the coroutine on a fresh thread with its own event loop.
+        try:
+            asyncio.get_running_loop()
+        except RuntimeError:
+            running_loop = False
+        else:
+            running_loop = True
+
+        if running_loop:
+            result: T | None = None
+            exception: BaseException | None = None
+            ctx = contextvars.copy_context()
+
+            def _run():
+                nonlocal result, exception
+                try:
+                    result = ctx.run(asyncio.run, coro)
+                except BaseException as e:
+                    exception = e
+
+            thread = threading.Thread(target=_run, daemon=True)
+            thread.start()
+            thread.join()
+
+            if exception is not None:
+                raise exception
+            return result  # type: ignore[return-value]
+
+        name = threading.current_thread().name + f"PID:{os.getpid()}"
         if name not in self._runner_map:
             if len(self._runner_map) > 500:
                 logger.warning(
diff --git a/tests/flytekit/unit/utils/test_asyn.py b/tests/flytekit/unit/utils/test_asyn.py
index 69d27f827a..9b332e23f7 100644
--- a/tests/flytekit/unit/utils/test_asyn.py
+++ b/tests/flytekit/unit/utils/test_asyn.py
@@ -168,3 +168,40 @@ async def runner_2():
         loop_manager.run_sync(runner_2)
 
     assert mock_handler.call_count == 2
+
+
+def test_run_sync_from_running_event_loop():
+    """Test that run_sync works when called from within a running event loop.
+
+    This simulates the scenario where FlyteRemote.execute() is called from
+    an async web framework (e.g., Flask with Gunicorn) that already has a
+    running event loop.
+    """
+
+    async def async_double(x: int) -> int:
+        await asyncio.sleep(0.001)
+        return x * 2
+
+    async def outer():
+        # We're inside a running event loop here.
+        # run_sync should detect this and use a fresh thread instead of _TaskRunner.
+        result = run_sync(async_double, x=21)
+        assert result == 42
+        return result
+
+    # Run the outer coroutine which will call run_sync from within a running loop
+    result = asyncio.run(outer())
+    assert result == 42
+
+
+def test_run_sync_from_running_event_loop_with_exception():
+    """Test that exceptions propagate correctly when run_sync is called from a running loop."""
+
+    async def async_fail():
+        raise ValueError("test error from async")
+
+    async def outer():
+        with pytest.raises(ValueError, match="test error from async"):
+            run_sync(async_fail)
+
+    asyncio.run(outer())