diff --git a/requirements/build.txt b/requirements/build.txt
index c661848..d9c5b6f 100644
--- a/requirements/build.txt
+++ b/requirements/build.txt
@@ -1,3 +1,3 @@
-build==1.3.0
-setuptools==80.9.0
+build==1.4.0
+setuptools==80.10.2
 setuptools_scm[toml]==9.2.2
diff --git a/requirements/dev.txt b/requirements/dev.txt
index 3b662b9..5b9079e 100644
--- a/requirements/dev.txt
+++ b/requirements/dev.txt
@@ -1,2 +1,2 @@
-tox==4.32.0
-GitPython==3.1.45
+tox==4.34.1
+GitPython==3.1.46
diff --git a/requirements/docs.txt b/requirements/docs.txt
index 9dfa820..be61f9d 100644
--- a/requirements/docs.txt
+++ b/requirements/docs.txt
@@ -1,4 +1,4 @@
 -r dev.txt
 
-sphinx==9.0.0
+sphinx==9.0.4
 
diff --git a/requirements/prd.txt b/requirements/prd.txt
index 142de54..24861b0 100644
--- a/requirements/prd.txt
+++ b/requirements/prd.txt
@@ -11,4 +11,4 @@ plotly-express==0.4.1
 biopython==1.86
 rdkit==2025.9.1
 pillow==11.2.1
-cachetools==6.2.1
\ No newline at end of file
+cachetools==6.2.6
\ No newline at end of file
diff --git a/requirements/test.txt b/requirements/test.txt
index fcc6331..bfc9a1e 100644
--- a/requirements/test.txt
+++ b/requirements/test.txt
@@ -1,6 +1,6 @@
-bandit==1.9.2
-ruff==0.14.7
-pytest==9.0.1
+bandit==1.9.3
+ruff==0.14.14
+pytest==9.0.2
 pytest-cov==7.0.0
-GitPython==3.1.45
+GitPython==3.1.46
 pytest-mock==3.15.1
\ No newline at end of file