When RealFuels is installed, KSP Interstellar's engines have the wrong thrust values. Essentially, no matter the choice of reactor, etc, the thrust is always fixed at a particular, arbitrary value.
The easiest way to reproduce this would be to get the CANDLE and turn it on. It always produces 4 kN in vacuum, no matter what type of fuel you give it, although the Isp does properly change.
This is more than a nuisance even though the wrong value is generally in the right order of magnitude, because MechJeb and other similar tools actually think that the maximum thrust is the correct value, when in reality it's stuck at, say, 4 kN for the CANDLE. This means that MechJeb starts burns at the wrong time, crashes probes attempting to use the landing autopilot, etc.