Vaccine/Diagnostics Development Pipelines
SARS-CoV-2 Peptide Vaccine, Gen 10
A project focused on the in silico design of a multi-epitope peptide vaccine against Monkeypox virus (MPXV) using immunoinformatics, epitope prediction, and molecular docking with TLR4.
Software for in silico identification of immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them
Group project for Fall 2020 Computational Medicine course.
Fall 2020 - Computational Medicine - course project
Peptide Vaccine Analysis Tool (PVAT) is an optimization software that predicts the best possible peptide stretches in a given protein sequence based on two factors: 1. the surface exposure of the peptide stretches, and 2. their susceptibility to mutation.
Glioblastoma (GBM) remains lethal despite multimodal therapy, with median survival under 15 months. Immunotherapy has failed in over 100 clinical trials due to three fundamental barriers: inadequate immune priming in "cold" tumors, blood–brain barrier (BBB) exclusion of therapeutics, and profound local immunosuppression.
This Python script generates multi-epitope vaccine constructs by combining permutations of cytotoxic T lymphocyte (CTL), helper T lymphocyte (HTL), and B cell epitopes. It uses linkers and adjuvants to create unique constructs, which are saved in FASTA format for further analysis.
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