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@LIVR-VUB

Liver Cell Biology Research Group - VUB

Deciphering liver cell diversity, fibrosis mechanisms, and regenerative pathways to create in vitro disease models and pinpoint biomarkers and therapy

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Liver Cell Biology Research Group(LIVR)

Brussels Health Campus • Vrije Universiteit Brussel • Brussels • Belgium

Other Links

  • LIVR-VUB Hugging Face: Hugging Face

Continers for HPC (Only for LIVR members)

When running large analysis or a custom program on HPC, its very important to run them containerized. Using containers prevents dependency conflicts and avoids issues that can arise from broken or mismatched software environments on the HPC.

  • Currently we support both Singularity Singularity and Docker Docker conatiners.
  • Important: On VSC clusters, only Singularity/Apptainer containers can be executed.
  • All of our custom containers are stored in Pixiu under the collection LIVR-Containers. If you need access to the the LIVR-Containers collection contact Arka.

Mission

Advance understanding of liver cell diversity, regeneration and fibrosis to drive novel biomarkers, in vitro disease models and therapeutic strategies for chronic liver disorders.


Research Objectives

  • Cellular Characterization
    Profile healthy vs. diseased liver cell types at single‑cell resolution.
  • Fibrosis Mechanisms
    Dissect pathways of hepatic stellate cell activation, fibrogenesis and resolution.
  • Biomarker Discovery
    Identify stellate‑cell‑specific markers for non‑invasive fibrosis staging.
  • Disease Modeling
    Build iPSC‑derived liver cell co‑cultures and organoids to recreate MASLD and other chronic conditions.
  • Regeneration & Progenitors
    Elucidate the role of liver progenitor cells in tissue repair.

Key Collaborations & Networks

  • ImAgE‑D (Marie Skłodowska‑Curie ITN, Oct 2023 – Sep 2027)
    High‑speed, super‑resolution imaging of endothelial and liver cells.
  • DeLIVERy (EIC Pathfinder, May 2022 – Apr 2026)
    Personalized polypharmacy testing on patient‑derived mini‑livers.

Publications & Resources

  • Latest Publications
    • JHEP Reports: “HSC single‑cell atlas reveals activation across etiologies”
    • Biofabrication: “iPSC‑derived liver spheroids to model fibrosis”
    • Science: “Hippo signaling instructs ectopic organ growth”
  • Full Publication List:
    Browse all publications (2010–present) Research Portal Click here.

Team & Training

  • Current Members | Former Members
    Explore profiles and roles on our Team page.
  • Doctoral & Post‑doc Training
    Interactive workshops, imaging courses, and 3R‑principle seminars for early‑career researchers.

News & Events

  • Belgian Stem Cell Meeting – Nov 28 2025 @ ULB Erasme Campus
  • Upcoming Seminars & “Film Nights” showcasing 3R approaches and mini‑liver therapies
  • Follow live updates in News & Events.

Contact

Laarbeeklaan 103, Building D – Room D022
1090 Brussels, Belgium
jmlazou@vub.be | +32 2 477 4409


“By unlocking liver cell biology, we pave the way for precision therapies in chronic liver disease.”

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  1. IA-HPC-Organoid-Quant IA-HPC-Organoid-Quant Public

    HPC-Organoid-Quant is a modular image analysis pipeline for quantifying organoids in brightfield microscopy images, with optional GFP analysis. It handles fragmented structures, extracts key featur…

    Jupyter Notebook 1

  2. HSC-Activation-Atlas HSC-Activation-Atlas Public

    Code and workflows for the study 'Hepatic stellate cell single-cell atlas reveals a highly similar activation process across liver disease aetiologies'—highlighting conserved HSC activation states …

    R

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