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Mathematical Foundations of Bioinformatics

Overview

  • Instructor: Alireza Fotuhi (ar.fotuhi at gmail.com) & Hesam Montazeri (hesam.montazeri at ut.ac.ir)
  • Teaching Assistants: Marzieh Gholami (at ut.ac.ir)
  • Time & Location: Sundays and Tuesdays 10:00-12:00 at Ghods st. 37, Department of Bioinformatics, IBB, Tehran.

Textbooks

  • [ITP] Blitzstein, Joseph K., and Jessica Hwang. Introduction to probability. Crc Press, 2019 (download)
  • [OpI] Diez, David M., Christopher D. Barr, and Mine Cetinkaya-Rundel. OpenIntro statistics. OpenIntro, Fourth Edition, 2019.
  • [MML] Deisenroth, Marc Peter, A. Aldo Faisal, and Cheng Soon Ong. Mathematics for machine learning. Cambridge University Press, 2020.
  • [DMA] Rosen, Kenneth H., and Kamala Krithivasan. Discrete mathematics and its applications: with combinatorics and graph theory. Tata McGraw-Hill Education, 2012.
  • [MSDA] John A. Rice, Mathematical Statistics And Data Analysis, Third edition, 2007.
  • [PRML] Pattern Recognition and Machine Learning by Christopher Bishop, 2006.

Previous Offerings

Lecture Schedule

Module A: Probability

Lecture Reading Assignments
Lecture A1- Introduction to probability; counting; Birthday paradox; story proof; probability axioms; inclusion-exclusion principle (slides, video A1) Required: ITP, Ch. 1
Lecture A2- conditional probability (slides)

Conditional probability; Two children problem (video A2-part 1)
Bayes’ rule; the law of total probability; Random coin problem; Testing for a rare disease (video A2-part 2)
Bayes' rule with extra conditioning, independenc; coherency of Bayes' rule (video A2-part 3)
Monty Hall problem, Simpson’s paradox, Gambler’s ruin (video A2-part 4)
Required: ITP, Ch. 2
Lecture A3- random variables and their distributions (slides)

Random variables; PMF (video A3-part 1)
Bernoulli and Binomial distributions (video A3-part 2)
Hypergeometric distribution (video A3-part 3)
Discrete Uniform distribution; Random slips of paper example (video A3-part 4)
Cumulative distribution function; independence of random variables (video A3-part 5)
Conditional independence; Fisher exact test (video A3-part 6)
Required: ITP, Ch. 3
Lecture A4- Expectation (slides)

Expectation; linearity of expectation (video A4-part 1)
Geometric and negative binomial distributions (video A4-part 2)
Indicator Random Variables (video A4-part 3)
LOTUS; Variance (video A4-part 4)
Poisson distribution (video A4-part 5)
Poisson approximation; Poisson & Binomial relationship (video A4-part 6)
Required: ITP, Ch. 4
Lecture A5- Continuous random variable (slides)

Introduction to continuous random variable (video A5-part 1)
Normal distribution (video A5-part 2)
Exponential distribution; Poisson process (Video A5-part 3)
Exponential distribution-continued (video A5-part 4)
Required: ITP, Ch. 5
Lecture A6- Moments (slides)

Summaries of a distribution (video 6-part 1)
Moment generating functions (video A6-part 2)
Required: ITP, Ch. 6



Programming assignments

Homeworks Deadline Tutorial
HW_P1 Mehr 6, 1401 Introduction to R, RStudio; Basic plotting functions in R By Sajedeh Bahonar (video)
HW_P2 Aban 11, 1401 Oncoplots



Textbook assignments

Textbook Chapter Homeworks
ITP Ch. 1 10, 11, 14, 18, 40, 49, 60
ITP Ch. 2 3, 37, 60, 62, 68, 73
ITP Ch. 3 1, 3, 8, 14, 19, 22, 26, 27, 30, 31, 34, 38
ITP Ch. 4 7, 16a, 26, 31, 33, 39, 49, 53, 54, 69, 71, 89, 91
ITP Ch. 5 1, 5, 8, 14, 22, 28, 40a, 41, 44, 45, 58, 61, 62ab
ITP Ch. 6 1, 15, 17, 22
OpI Ch. 1 2, 4, 8, 10, 22, 30, 34, 38, 40, 42
OpI Ch. 2 2, 6, 10, 14, 16, 22, 28, 34
OpI Ch. 5 4, 6, 8, 10, 12
MSDA Ch. 7 67
MSDA Ch. 8 7a-c, 45

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