Aptamers are single stranded nucleotides, with applications comparable to those of antibodies - targeted drug delivery, bio-sensors etc - while being more chemically malleable.
In this repo, we compile the tools and data utilized during the development of the work: 'Designing in silico aptamers for potential marine bioremediation'.
/Database/AptaComContains a non redundant array of data from various aptamer databases:- The dataset describes aptamers, their targets and their interaction as follows:
| Aptamer (A) | A.Chemistry | A.Sequence | Target (T) | T.Chemistry | T.Sequence | T.External ID | Affinity | Reference | DOI | Origin |
|---|---|---|---|---|---|---|---|---|---|---|
| Name | DNA/RNA | 'AGCGATGCATG' | Name | Protein/Small Molecule | 'MAEVLTLAT' | PDB/PubChem/ATCC | 0.9pM | Li.et Al | ---- | UTexas/AptaDB... |
/Modeldescribes a XGBoost model built for predicting aptamer target interactions (Binding vs No Binding)- For more details: https://github.com/rpgv/AptaCom/tree/main/Model
Click here to access
